Conn`s Syndrome or Primary aldosteronism (PA) is a group of disorders in which aldosterone production is inappropriately high, relatively autonomous from the renin – angiotensin system, and non suppressible by sodium loading.
Prevalence of PA in unselected hypertensive population is around 2%. Usually seen in 4- 5th decades and is more common among women. Common symptoms includes
- Hypertension: Moderate to Severe
- Hypokalemia (Low potassium) associated with weakness , cramps or periodic muscle paralysis
Diagnosis is usually confirmed by High Plasma Angiotensin Renin ratio > 30 along with adrenal tumour.
Treatment usually involves Unilateral Minimal Invasive Adrenalectomy.
Patients with stage 2 (160 – 179 / 100 – 109 mm Hg), stage 3 (180/110 mmHg), or drug-resistant hypertension, Hypertension and spontaneous or diuretic-induced hypokalemia, Hypertension with adrenal incidentaloma , Hypertension and a family history of early-onset hypertension or CVA at a young age (40 yr) or patients with first-degree relatives with PA are candidate for screening