It is the syndrome associated with hypercortisolism. Cause can be from Pituitary, Adrenal, Exogenous (i.e external steroid intake) or from any cortisol secreting cancer. Symptoms may vary according to the site of production, however common symptoms include:
|Truncal obesity, rounded face||90%|
|Thin skin, easy bruising, striae||65%|
|Proximal muscle weakness||60%|
Impaired blood glucose, loss of libido etc.
Screening test includes Screening test consists of 24 hr urinary free cortisol, Night time cortisol (Serum, salicary), Overnight low dose dexamethasone suppression test. Confirmatory test may include Low Dose Dexamethasone suppression test and ACTH.
Treatment options includes Adrenalectomy, Endoscopic Pituitary surgery or Removal of Extra-adrenal tumour.